FIGURE

Fig. 5

ID

ZDB-FIG-110407-5

Publication

Padanad et al., 2011 - Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24

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Fig. 5

pax2/8 regulates otic expression of fgf24. (A, C, F) fgf24 expression in the otic placode in control embryos at 11 hpf (A), 13 hpf (C) and 18 hpf (F). (B, D, G) fgf24 expression in pax8 morphants at 11hpf (B), 13 hpf (D) and 18 hpf (G). Expression of fgf24 is lost from preotic placodes in pax8 morphants at 11 hpf (B) and is reduced in pax8 morphants at 13 hpf (D) and 18 hpf (G). (E, H) noi (pax2a) mutants co-injected with pax8-MO and pax2b-MO showing loss of otic expression of fgf24 at all time points. Expression in pharyngeal (pa) arches and the otic vesicle (ov) is indicated. Images show dorsal views with anterior to the top (A–E); lateral views with anterior to the left and dorsal to the top (F–H).

Expression Data

Gene:	fgf24
Fish:	AB AB + MO6-pax8 + MO7-pax8 pax2a^tu29a/tu29a + MO1-pax2b + MO6-pax8 + MO7-pax8
Knockdown Reagents:	MO1-pax2b MO6-pax8 MO7-pax8
Anatomical Terms:	otic placode otic vesicle pharyngeal arch
Stage Range:	1-4 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 351(1), Padanad, M.S., and Riley, B.B., Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24, 90-98, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.