ZFIN Morpholino: MO1-pax2b

Target Location

Genome Build: GRCz11Chromosome: 12

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-pax2b

Expressed Gene	Anatomy	Figures
pax8	(not) trunk	Fig. S1 from Batista et al., 2008
six1b	otic vesicle	Fig. 11 from Bricaud et al., 2006

Phenotype

Phenotype resulting from MO1-pax2b

No data available

Phenotype of all Fish created by or utilizing MO1-pax2b

Phenotype	Fish	Conditions	Figures
otic vesicle lacks all parts of type otolith, abnormal	WT + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005
otic vesicle decreased size, abnormal	WT + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005
otic vesicle morphogenesis process quality, abnormal	WT + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005
otic vesicle development decreased process quality, abnormal	pax2a^tu29a/tu29a + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005
whole organism lacks all parts of type otic vesicle, abnormal	pax2a^tu29a/tu29a + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005
epibranchial ganglion decreased amount, abnormal	pax2a^tu29a/tu29a + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 3 from Padanad et al., 2011
otic vesicle physical object quality, abnormal	pax2a^tu29a/tu29a + MO1-pax2b + MO6-pax8 + MO7-pax8	standard conditions	Fig. 5 from Mackereth et al., 2005

Citations

Include unpublished citations

D'Aniello, E., Ravisankar, P., Waxman, J.S. (2015) Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS One. 10:e0138588
Padanad, M.S., and Riley, B.B. (2011) Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. Developmental Biology. 351(1):90-98
Sweet, E.M., Vemaraju, S., and Riley, B.B. (2011) Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear. Developmental Biology. 358(1):113-21
Batista, M.F., and Lewis, K.E. (2008) Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Developmental Biology. 323(1):88-97
Millimaki, B.B., Sweet, E.M., Dhason, M.S., and Riley, B.B. (2007) Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch. Development (Cambridge, England). 134(2):295-305
Bricaud, O., and Collazo, A. (2006) The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(41):10438-10451
Mackereth, M.D., Kwak, S.J., Fritz, A., and Riley, B.B. (2005) Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode. Development (Cambridge, England). 132(2):371-382

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