FIGURE

Fig. 4

ID

ZDB-FIG-110111-4

Publication

Gjini et al., 2011 - Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

Other Figures

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Fig. 4

tie-2 mutants develop normal blood and lymphatic vasculature. (A) Confocal microscopy of trunk vessels in 5-day-old wild-type (Ai) and tie-2 mutant (Aii) embryos in the Tg(fli1:EGFP) background. Loss of Tie-2 protein does not affect blood and lymphatic vessel formation (Aii,iv) in zebrafish as compared to the wild-type blood (Ai) and lymphatic (Aiii) vessel development. (B) A test for functionality of the thoracic duct shows dye uptake in both wild-type siblings (Bi) and tie-2 mutants (Bii). Angiographies were performed in Bi and Bii to highlight the dorsal aorta (DA) and PCV. ISV, intersegmental vessels; TD, thoracic duct; DLAV, dorsal longitudinal anastomotic vessel.

Expression Data

Gene:	EGFP
Fish:	y1Tg tek^{hu1667/hu1667}; y1Tg
Anatomical Term:	blood vasculature
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tek^{hu1667/hu1667}; y1Tg
Observed In:	blood vessel development lymph vasculature lymph vessel development vasculature
Stage:	Day 5

Phenotype Detail

Acknowledgments

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