FIGURE

Fig. 5

ID

ZDB-FIG-110111-5

Publication

Gjini et al., 2011 - Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

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Fig. 5

Lack of Tie-2 protects zebrafish embryos from cranial hemorrhages caused by treatment with statins. (A) Graphic representation (in percentage) of hemorrhagic (orange bars) and non-hemorrhagic (yellow bars) groups for wild-type siblings (i) and tie-2 mutants (ii) after exposure to increasing concentrations of atorvastatin; the numbers of hemorrhagic (orange bars) and non-hemorrhagic (yellow bars) groups for wild-type siblings (iii) and tie-2 mutants (iv) after exposure to increasing concentrations of simvastatin are shown. (B) tie-2 mutants show similar cranial hemorrhages (arrow) as the wild-type embryos after treatment with atorvastatin. (C) No cranial hemorrhages are observed in wild-type siblings and tie-2 mutants as shown by o-dianizidine staining. However, treatment with 1000 nM atorvastatin causes cranial hemorrhages in the head region of both genotypic groups (asterisks show the regions in the head area of siblings and mutants where blood is accumulating).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT tek^{hu1667/hu1667}
Condition:	chemical treatment: atorvastatin calcium
Observed In:	cranial blood vessel
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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