Fig. 2
- ID
- ZDB-FIG-110111-35
- Publication
- Bresciani et al., 2010 - Zebrafish numb and numblike are involved in primitive erythrocyte differentiation
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The nb/nbl knockdown affects erythrocytes development. A?B. The general morphology of 48 hpf nb/nbl morphants is substantially unaffected (B) when compared to control embryos (A). C. Hematopoietic defects in nb/nbl morphants at 48 hpf: ∼60% of the nb/nbl morphants displayed a severe hematopoietic defect (n = 191). 100% of control embryos was unaffected (n = 93). *** p<0.001 vs std MO. D?I. Detailed images of the blood flow in the trunk-tail region of 48 hpf Tg(gata1:dsRed) embryos injected with std MO (0.8 pmol/embryo; D, E) and nb/nbl MO (0.8 pmol/embryo; G, H). In nb/nbl morphants no circulating red cells are detectable within the trunk vasculature. Whole embryo o-dianisidine staining on 48 hpf std MO embryos (F) and nb/nbl morphants (I). L?M′. Longitudinal semithin plastic sections of std MO (L, L′) and nb/nbl MO-injected embryos (M, M′) at 2 dpf. Fewer elements are detectable within the Dorsal Aorta (DA) and the Caudal Vein (CV) in nb/nbl morphants when compared to control embryos. L′, M′: higher magnification of L, M. |
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| Fish: | |
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| Anatomical Term: | |
| Stage: | Long-pec |
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| Knockdown Reagent: | |
| Observed In: | |
| Stage: | Long-pec |