FIGURE

Fig. 1

ID

ZDB-FIG-101105-36

Publication

Jurynec et al., 2010 - SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo

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Fig. 1

The zebrafish Ship2a protein and expression of maternal ship2a transcripts. (A) The structure of the zebrafish Ship2a protein and the percentage identity between the signature domains of the zebrafish and human SHIP2 protein sequences. The zebrafish Ship2a protein contains motifs that are highly conserved among IPPc catalytic domains. SH2, src homology 2; IPPc, inositol polyphosphate 5-phosphatase catalytic domain; PRD, proline-rich domain; SAM, sterile alpha-motif. (B) Unrooted phylogenetic tree based on Clustal W protein sequence alignments, indicating the relatedness of zebrafish and human SHIP1 and SHIP2 proteins. (C-E) Zebrafish ship2a is maternally supplied and broadly expressed throughout early development. ship2a expression is shown in whole embryos (diameter -0.8 mm) at the one-cell (C), eight-cell (D) and 50% epiboly (5.3 hpf) (E) stages.

Expression Data

Gene:	inppl1a
Fish:	AB
Anatomical Terms:	blastoderm blastodisc
Stage Range:	1-cell to 50%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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