Gene
inppl1a
- ID
- ZDB-GENE-030131-3904
- Name
- inositol polyphosphate phosphatase-like 1a
- Symbol
- inppl1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have actin binding activity and hydrolase activity. Involved in BMP signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; and negative regulation of neutrophil chemotaxis. Predicted to localize to nuclear speck. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Is expressed in blastoderm and blastodisc. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Jurynec et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Opsismodysplasia | 258480 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000300 | Inositol polyphosphate-related phosphatase |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Endonuclease/exonuclease/phosphatase superfamily | Inositol polyphosphate-related phosphatase | SH2 domain | SH2 domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q2I6J1
|
1266 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
inppl1a-201
(1)
|
Ensembl | 4,238 nt | ||
| mRNA |
inppl1a-202
(1)
|
Ensembl | 3,083 nt | ||
| mRNA |
inppl1a-203
(1)
|
Ensembl | 781 nt |
Interactions and Pathways
No data available
Plasmids
No data available