Gene
inppl1a
- ID
- ZDB-GENE-030131-3904
- Name
- inositol polyphosphate phosphatase-like 1a
- Symbol
- inppl1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable inositol-polyphosphate 5-phosphatase activity. Acts upstream of or within BMP signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; and negative regulation of neutrophil chemotaxis. Predicted to be located in nuclear speck. Predicted to be active in cytosol. Is expressed in blastoderm and blastodisc. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Jurynec et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Opsismodysplasia | 258480 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000300 | Inositol polyphosphate-related phosphatase |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Endonuclease/exonuclease/phosphatase superfamily | Inositol polyphosphate-related phosphatase | SH2 domain | SH2 domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q2I6J1
|
1266 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
inppl1a-201
(1)
|
Ensembl | 4,238 nt | ||
| mRNA |
inppl1a-202
(1)
|
Ensembl | 3,083 nt | ||
| mRNA |
inppl1a-203
(1)
|
Ensembl | 781 nt |
Interactions and Pathways
No data available
Plasmids
No data available