FIGURE

Fig. 6

ID

ZDB-FIG-100706-41

Publication

Flores et al., 2010 - Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies

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Fig. 6

Effects of chemicals on lymphangiogenesis can be examined by monitoring expression of lyve1. A-C: Specification of lymphatic progenitors was not affected by lyve1 MO (A), but by prox1 MO (B,C), in 26 hpf embryos; blood vessel formation was unaltered (C). D-I: vegfc MO or 400 nM rapamycin reduced lymphatic budding and sprouting in 54 hpf embryos. J-L: Blood vessels remained normal in control and test embryos. All lateral views, except for D-F, which are dorsal views. TD, thoracic duct.

Expression Data

Genes:	cdh5 lyve1b
Fish:	WT WT + MO1-lyve1b WT + MO1-prox1a WT + MO3-vegfc + MO4-vegfc
Condition:	chemical treatment: sirolimus
Knockdown Reagents:	MO1-lyve1b MO1-prox1a MO3-vegfc MO4-vegfc
Anatomical Terms:	blood vasculature lymphatic system
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT WT + MO1-lyve1b WT + MO1-prox1a WT + MO3-vegfc + MO4-vegfc
Condition:	chemical treatment: sirolimus
Knockdown Reagents:	MO1-lyve1b MO1-prox1a MO3-vegfc MO4-vegfc
Observed In:	blood vasculature lymph vessel development lymphatic endothelial cell differentiation whole organism
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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