FIGURE

Fig. 5

ID

ZDB-FIG-100616-4

Publication

McGrail et al., 2010 - Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organs

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Fig. 5

Increased expression of prom1a and prom1b in epitheloid-like cells in tp53^M214K/tp53^M214K induced neoplasm. A, B, E, F: Gross morphology and histopathology of abdominal (A, B) and ocular (E, F) neoplasms in 12-month-old adult homozygous tp53^M214K/tp53M214K zebrafish. B: Histopathological features of the abdominal neoplasm show regions with predominantly spindle cells (solid line box) or predominantly epitheloid cells (dashed line box), consistent with a diagnosis of zMPNST (Berghmans et al., [2005]). F: Histopathological features of ocular tumor show predominantly spindle cells, consistent with a diagnosis of zMPNST (Berghmans, et al., 2005). C, D: Expression of prom1a (C) and prom1b (D) is detected within epitheloid-like cells in the abdominal neoplasm (solid line box), but is absent from the region containing predominantly spindle cells (dashed line box). G, H: Absence of expression of prom1a (G) and prom1b (H) in spindle cells of the ocular neoplasm. Scale bars in A, E = 0.5 cm; in H = 50 μm.

Expression Data

Genes:	prom1a prom1b
Fish:	WT
Anatomical Term:	unspecified
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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