Gene

prom1b

ID

ZDB-GENE-031003-1

Name

prominin 1 b

Symbol

prom1b Nomenclature History

Previous Names

proml2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have cholesterol binding activity. Localizes to apical plasma membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Is expressed in nervous system; otic vesicle; and testis. Orthologous to human PROM1 (prominin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146277 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from Lu et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prom1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cone-rod dystrophy 12	Alliance	Cone-rod dystrophy 12	612657
retinal macular dystrophy 2	Alliance	Macular dystrophy, retinal, 2	608051
retinitis pigmentosa 41	Alliance	Retinitis pigmentosa 41	612095
Stargardt disease	Alliance	Stargardt disease 4	603786

Associated With prom1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008795	Prominin

Domain Details Per Protein

Protein	Length	Prominin
UniProtKB:A0A8M9QPM2 InterPro	877
UniProtKB:A0A8M2BI60 InterPro	867
UniProtKB:A0A8M9QPR6 InterPro	866
UniProtKB:A0A8M9QH22 InterPro	872
UniProtKB:A0A8M9Q036 InterPro	874
UniProtKB:A0A8M9Q021 InterPro	875
UniProtKB:A0A8M9QPL4 InterPro	880
UniProtKB:Q90WI3 InterPro	851
UniProtKB:A0A8M9QBM3 InterPro	883

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prom1b-201 (1) Ensembl	Ensembl	3,885 nt	Select Tool
mRNA	prom1b-202 (1) Ensembl	Ensembl	546 nt	Select Tool
mRNA	prom1b-203 (1) Ensembl	Ensembl	371 nt	Select Tool
mRNA	prom1b-204 (1) Ensembl	Ensembl	2,556 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-prom1b	polyclonal	prom1b		Rabbit			1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations