FIGURE

Fig. 6

ID

ZDB-FIG-091121-6

Publication

Pittman et al., 2008 - Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points

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Fig. 6

Pioneer axons influence pathfinding of follower axons. (A) Transplants resupply early RGCs to brn3c:GFP hosts injected with ath5 MO. (B-E) Dorsal views at 5 dpf, rostral upwards. Host axons terminate peripherally on the tectum; errors indicated by stars. (B′-E′) Error quantitation. (B,B′) In wild type>wild type;ath5 MO transplants, host follower axons pathfind normally. (C,C′) When pioneers are replaced with ast cells, wild type follower axons make significantly more mistakes. (D,D′) In ast>ast;ath5MO transplants, host follower axons make many errors. (E,E′) When pioneers are replaced with wild-type cells, follower ast axons make fewer errors but are not completely rescued. Scale bar: 50 μm.

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