FIGURE

Fig. 5

ID

ZDB-FIG-090804-5

Publication

Kurrasch et al., 2009 - Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish

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Fig. 5

Accumulated neuropeptide protein and the buildup of endoplasmic reticulum-like membranes in nsf^st53zebrafish. The levels of (A, B) hypocretin and (C, D) NPY protein in wild-type (WT) and nsf^st53zebrafish are shown (n = 8 each). Protein levels are increased in the soma (B, D). DAPI stained nuclei are also shown (A-D). Electron microscopy images from (E) wild-type and (F) nsf^st53zebrafish (n = 3 each). For EM analysis, neuroanatomical landmarks (obtained from [50]) and the presence of dense-core vesicles (Figure 4I) were used to locate the hypothalamus. The budding of secretory vesicles from the trans-Golgi network is highlighted (E, red arrowhead). A build up of ribosome-bound ER-like membranes in nsf^st53zebrafish is noted (F, red arrowhead). PM = plasma membrane.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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