FIGURE

Fig. 2

ID

ZDB-FIG-090304-57

Publication

Feijoo et al., 2009 - Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a

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Fig. 2

irx4a regulates sox2 expression in the neural plate. In situ hybridization of brain markers was carried out on control and irx4a morphant embryos at 90% epiboly. (A, B) The neural precursor marker sox2 appears diminished in the anterior brain (ab) and hindbrain (presumptive rhombomere 3, arrowhead, pr3) in irx4a morphant embryos (B) compared to uninjected controls (A). (C, D) The expression pattern of pax2.1 in the midbrain–hindbrain boundary (pMB-HB) appears unaffected but the expression of the rhombomere 3 marker krox20 (arrowhead) is diminished in morphant embryos. (E, F) rx3 expression in the presumptive forebrain (pf) is unchanged in morphant compared to control embryos. All views are dorsal, anterior is towards the left.

Expression Data

Genes:	egr2b pax2a rx3 sox2
Fish:	WT WT + MO5-irx4a
Knockdown Reagent:	MO5-irx4a
Anatomical Terms:	anterior neural plate forebrain neural plate hindbrain neural plate midbrain hindbrain boundary neural plate
Stage:	90%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 40(3), Feijoo, C.G., Saldias, M.P., De la Paz, J.F., Gómez-Skarmeta, J.L., and Allende, M.L., Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a, 328-337, Copyright (2009) with permission from Elsevier. Full text @ Mol. Cell Neurosci.