FIGURE

Fig. 6

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ZDB-FIG-090127-63

Publication

Davis et al., 2009 - The role of the granuloma in expansion and dissemination of early tuberculous infection

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Fig. 6

Departing Bacteria form Secondary Granulomas

(A–C) Bacteria from one granuloma spread to another. (A) Primary granuloma immediately after photoactivation at 3 dpi. Scale bar, 50 μm. (B) At 5 dpi, the original granuloma (1) persists and a new one (2) has appeared nearby. Dashed box, area shown in panel C. (C) Photoactivated bacteria from granuloma 1 spreading in granuloma 2. Scale bar, 10 μm.

(D) Single granuloma at 3 dpi (white arrow, 1) with departure of bacteria to new location 24 hr later (white arrowhead). By 48 hr, the original granuloma (1) continues to grow, the new locus is forming a granuloma (2), and a third locus of infection has appeared (arrowhead). Scale bar, 300 μm.

(E) Dissemination from single primary granulomas in ten embryos. Horizontal lines indicate fate of departing macrophages (remain single or form granuloma) on successive days. ^*Indicates dissemination of multiple macrophages that could not be tracked definitively between days or that appeared on the last day of tracking. The embryo from (D) is shown as 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 136(1), Davis, J.M., and Ramakrishnan, L., The role of the granuloma in expansion and dissemination of early tuberculous infection, 37-49, Copyright (2009) with permission from Elsevier. Full text @ Cell