FIGURE

Fig. 6

ID

ZDB-FIG-081202-6

Publication

Rodriguez et al., 2008 - The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development

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Fig. 6

Synergistic effects of Dep1a and Dep1b MOs. Dep1a- and Dep1b-MOs were (co-)injected at the 1-cell stage (4 ng each) and the embryos were fixed at 30 hpf. In situ hybridizations were done using tbx20 specific probes (A?D), a cdh5 (ve-cadherin)-specific probe (E,F) or myoD-specific probes (G,H). (I) Quantification of defects in tbx20 expression, classified as outlined in Fig. 5. The total number of embryos that was analyzed for each condition from three independent experiments is indicated here and depicted in Supplementary Table S2.

Expression Data

Genes:	cdh5 myod1 tbx20
Fish:	AB/TL AB/TL + MO1-ptprja AB/TL + MO1-ptprjb.1 AB/TL + MO1-ptprja + MO1-ptprjb.1
Knockdown Reagents:	MO1-ptprja MO1-ptprjb.1
Anatomical Terms:	axial vasculature blood vessel endothelial cell dorsal aorta somite
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL + MO1-ptprja AB/TL + MO1-ptprjb.1 AB/TL + MO1-ptprja + MO1-ptprjb.1
Knockdown Reagents:	MO1-ptprja MO1-ptprjb.1
Observed In:	artery morphogenesis dorsal aorta somite somitogenesis vasculogenesis
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 324(1), Rodriguez, F., Vacaru, A., Overvoorde, J., and den Hertog, J., The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development, 122-130, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.