Fig. 2
- ID
- ZDB-FIG-081117-20
- Publication
- Chung et al., 2008 - Bmp2 signaling regulates the hepatic versus pancreatic fate decision
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bmp2b Is Expressed in the Lateral Plate Mesoderm from an Early Stage (A–D) Dorsal views (A and C) and transverse sections (B and D) showing bmp2b expression (dotted squares and white arrows) in the lateral plate mesoderm starting at the 10 somite stage (A and B) and persisting through the 14 somite stage (C and D). At the 10-somite stage, bmp2b starts to be expressed in the lateral plate mesoderm (A and B). The expression becomes more pronounced by the 14 somite stage (C and D). Note that the dispersed bmp2b expression at the 10 somite stage becomes more discrete by the 14 somite stage. (E) Dorsal view of two-color in situ hybridization (myod1 in red and bmp2b in blue) showing that bmp2b is expressed adjacent to somites 1 through 3 at the 10 somite stage (dotted square). (F) Confocal image of a transverse section showing the location of the lateral 2 endodermal cells (L2) in relation to the LPM (yellow dotted circle). Embryos were stained for Fibronectin (green) and ZO1 (red) and counterstained with Topro (white). A yolk syncytial layer (YSL) nucleus is marked with an asterisk. (G and H) Dorsal views of pdx1 expression, comparing wild-type (G) and smo mutant (H) at the 10 somite stage. pdx1 is expressed at high levels in the most medial cells (asterisks) and at low levels in the lateral cells (arrows) in wild-type (G). Low-level pdx1 expression (arrows) is detected in smo mutant starting at the 10 somite stage (H). |
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| Stage Range: | 10-13 somites to 14-19 somites |
Reprinted from Developmental Cell, 15(5), Chung, W.S., Shin, C.H., and Stainier, D.Y., Bmp2 signaling regulates the hepatic versus pancreatic fate decision, 738-748, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell