ZFIN Fish: smo^hi1640Tg/hi1640Tg

ZFIN ID: ZDB-FISH-150901-26628

ZFIN ID: ZDB-FISH-150901-26628

Fish name:	smo^{hi1640Tg/hi1640Tg}
Genotype:	smo^{hi1640Tg/hi1640Tg}
Targeting Reagent:	none

HUMAN DISEASE MODELED by smo^{hi1640Tg/hi1640Tg}
No data available

GENE EXPRESSION
Gene expression in smo^{hi1640Tg/hi1640Tg}

RNA expression

Expressed Gene	Structure	Conditions	Figures
cldnb	(not) optic stalk (not) otic vesicle	standard conditions	Fig. 4 from Bergeron et al., 2008
cxcr4b	(not) dorsal habenular nucleus	control	Fig. 4 from Roberson et al., 2017
dbx1b	(not) dorsal habenular nucleus	control	Fig. 4 from Roberson et al., 2017
fsta	central nervous system diencephalon epiphysis (not) hindbrain midbrain optic tectum somite	standard conditions	Fig. 2 from Bergeron et al., 2008
fstl1b	central nervous system (not) diencephalon (not) midbrain somite	standard conditions	Fig. 2 from Bergeron et al., 2008
ins	(not) whole organism	standard conditions	Fig. S1 from Chung et al., 2008
irx1b	hindbrain midbrain notochord spinal cord	standard conditions	Fig. 4 from Bergeron et al., 2008
lama1	central nervous system anterior region eye pronephric duct pronephric duct opening segmental plate spinal cord vasculature	control	Fig. 3 from Pickering et al., 2017
myca	(not) eye liver (not) optic tectum	standard conditions	Fig. 5 from Milla et al., 2012
neo1a	(not) notochord (not) retinal ganglion cell layer	standard conditions	Fig. 4 from Milla et al., 2012
neurod1	diencephalon hindbrain (not) pancreatic bud telencephalon	standard conditions	Fig. 4 from Bergeron et al., 2008
nkx2.2a	brain (not) neural tube	standard conditions	Fig. 5 from Zhao et al., 2016
nos2b	(not) splanchnocranium	control	Fig. 2 from Poon et al., 2008
nr5a1a	forebrain (not) interrenal primordium optic stalk	standard conditions	Fig. 3 from Bergeron et al., 2008
olig2	brain (not) neural tube	standard conditions	Fig. 5 from Zhao et al., 2016
pax3a	hindbrain midbrain somite spinal cord	standard conditions	Fig. 5 from Bergeron et al., 2008
pdx1	anterior pancreatic bud endoderm gut pancreas primordium	standard conditions	Fig. S1 from Chung et al., 2008 Fig. 2 from Chung et al., 2008
prdm1a	(not) adaxial cell ectoderm	standard conditions	Fig. 1 , Fig. 2 from Liew et al., 2008
prox1a	(not) myotome (not) slow muscle cell	standard conditions	Fig. 1 , Fig. 2 from Aanstad et al., 2009 Fig. 4 from Liew et al., 2008
ptch2	brain (not) neural tube	standard conditions	Fig. 5 from Zhao et al., 2016
rab3c	diencephalon hindbrain midbrain spinal cord telencephalon	standard conditions	Fig. 6 from Bergeron et al., 2008
smyhc1	muscle slow muscle cell	standard conditions	Fig. 5 , Fig. 6 from Elworthy et al., 2008
smyhc2	caudal oblique cephalic musculature (not) infracarinalis	standard conditions	Fig. 5 from Elworthy et al., 2008
ubr3	(not) somite	standard conditions	Fig. S5 from Li et al., 2016
wt1a	pronephros	standard conditions	Fig. 3 from Bergeron et al., 2008

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab1-tuba		Kupffer's vesicle motile cilium	standard conditions	Fig. 3 from Stiff et al., 2016
Ab1-eng		fast muscle cell muscle pioneer (not) myotome	standard conditions	Fig. 3 from Hoshijima et al., 2019 Fig. 1 , Fig. 2 from Aanstad et al., 2009
Ab-S58		caudal oblique slow muscle cell supracarinalis	standard conditions	Fig. 5 from Elworthy et al., 2008
Ab-F59		myotome (not) slow muscle cell	standard conditions	Fig. 1 , Fig. 2 from Aanstad et al., 2009 Fig. 4 from Liew et al., 2008
Ab5-prox1		muscle pioneer slow muscle cell	standard conditions	Fig. 3 from Hoshijima et al., 2019
Ab3-prox1	prox1a	(not) slow muscle cell	standard conditions	Fig. 4 from Liew et al., 2008

Reporter gene expression No data available

PHENOTYPE
Phenotype in smo^{hi1640Tg/hi1640Tg}

Phenotype	Conditions	Figures
brain nkx2.2a expression decreased amount, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
brain olig2 expression decreased amount, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
brain ptch2 expression decreased amount, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
cellular senescence increased magnitude, abnormal	standard conditions	text only from Kishi et al., 2008
central nervous system anterior region lama1 expression decreased amount, abnormal	control	Fig. 3 from Pickering et al., 2017
dorsal habenular nucleus dbx1b expression absent, abnormal	control	Fig. 4 from Roberson et al., 2017
dorsal habenular nucleus cxcr4b expression absent, abnormal	control	Fig. 4 from Roberson et al., 2017
eye myca expression absent, abnormal	standard conditions	Fig. 5 from Milla et al., 2012
eye decreased distance eye, abnormal	standard conditions	text only from Kishi et al., 2008
eye decreased size, abnormal	standard conditions	text only from Kishi et al., 2008
fast muscle cell absent, abnormal	standard conditions	Fig. 3 from Hoshijima et al., 2019
inner ear has extra parts of type lateral crista, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
inner ear has extra parts of type anterior macula, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
inner ear lacks all parts of type posterior macula, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
inner ear posterior region anteriorized, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
inner ear morphogenesis decreased process quality, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
Kupffer's vesicle motile cilium decreased length, abnormal	standard conditions	Fig. 3 from Stiff et al., 2016
lateral floor plate aplastic, abnormal	standard conditions	text only from Kishi et al., 2008
liver myca expression decreased amount, abnormal	standard conditions	Fig. 5 from Milla et al., 2012
muscle cell differentiation process quality, abnormal	standard conditions	Fig. 1 , Fig. 2 from Aanstad et al., 2009
muscle pioneer absent, abnormal	standard conditions	Fig. 3 from Hoshijima et al., 2019 Fig. 1 , Fig. 2 from Aanstad et al., 2009
neural tube ptch2 expression absent, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
neural tube nkx2.2a expression absent, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
neural tube olig2 expression absent, abnormal	standard conditions	Fig. 5 from Zhao et al., 2016
notochord neo1a expression absent, abnormal	standard conditions	Fig. 4 from Milla et al., 2012
optic tectum myca expression absent, abnormal	standard conditions	Fig. 5 from Milla et al., 2012
otolith fused with otolith, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
pancreas development disrupted, abnormal	standard conditions	Fig. S1 from Chung et al., 2008
pericardium edematous, abnormal	standard conditions	text only from Kishi et al., 2008
pronephric duct opening lama1 expression decreased amount, abnormal	control	Fig. 3 from Pickering et al., 2017
retinal ganglion cell layer neo1a expression absent, abnormal	standard conditions	Fig. 4 from Milla et al., 2012
sagitta decreased size, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
sagitta mislocalised ventrally, abnormal	standard conditions	Fig 1 from Hartwell et al., 2019
secondary motor neuron absent, abnormal	standard conditions	text only from Kishi et al., 2008
segmental plate lama1 expression decreased amount, abnormal	control	Fig. 3 from Pickering et al., 2017
slow muscle cell absent, abnormal	standard conditions	Fig. 3 from Hoshijima et al., 2019 Fig. 1 , Fig. 2 from Aanstad et al., 2009
somite ubr3 expression absent, abnormal	standard conditions	Fig. S5 from Li et al., 2016
somite U-shaped, abnormal	standard conditions	text only from Kishi et al., 2008
trunk curved ventral, abnormal	standard conditions	text only from Kishi et al., 2008
whole organism decreased thickness, abnormal	standard conditions	text only from Kishi et al., 2008
yolk grey, abnormal	standard conditions	text only from Kishi et al., 2008
yolk morphology, abnormal	standard conditions	text only from Kishi et al., 2008

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