Gene

bmp2b

ID
ZDB-GENE-980526-474
Name
bone morphogenetic protein 2b
Symbol
bmp2b Nomenclature History
Previous Names
  • bmp2-4
  • zbmp-2
  • zbmp2
  • cb670 (1)
  • etID309839.20 (1)
  • swirl
  • swr
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits identical protein binding activity and protein heterodimerization activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and gastrulation. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; ectoderm; fin; and mesoderm. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).
Genome Resources
Note
None
Expression
All Expression Data
161 figures from 122 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
35 figures from 22 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type A2 Alliance Brachydactyly, type A2 112600
hemochromatosis type 1 Alliance {HFE hemochromatosis, modifier of} 235200
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 617877
Associated With bmp2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:O57573 411
UniProtKB:O13108 411
UniProtKB:O93369 411
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations