FIGURE

Fig. 4

ID

ZDB-FIG-081010-11

Publication

Gansner et al., 2008 - Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

pfd^gw1 mutants are sensitized to pharmacologic inhibition of lysyl oxidase. A-F: Clutches from pfd^gw1/+ intercrosses were incubated in vehicle (A,B), the copper chelator neocuproine (2 μM; C,D), or the lysyl oxidase inhibitor β-aminopropionitrile (1 mM; E,F). Notochord is normal in wild-type embryos treated with vehicle or neocuproine (A,C) and shows a very mild herniation event in β-aminopropionitrile (E, arrowhead). Notochords of pfd^gw1 mutants in neocuproine and β-aminopropionitrile (D,F, arrowheads) are substantially more distorted than mutants incubated in vehicle (B, arrowhead). Embryos were incubated in PTU to inhibit melanin pigmentation and photographed at 30 hours postfertilization (hpf).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fbn2b^gw1/gw1 (AB)
Observed In:	caudal vein median fin fold notochord trunk trunk integument
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.