FIGURE

Fig. 9

ID
ZDB-FIG-080828-14
Publication
Dee et al., 2008 - Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm
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Fig. 9

Sox3 knock-down causes abnormal development of the ear and cranial placodes. All embryos are aged 24 hpf. Otic vesicles of control (A, arrow indicates otolith) and sox3 morphant (B–D) embryos showing reduced (B, 25/49 embryos), split (C, 10/49), or absent vesicles (D, 14/49). (E–H) In situ hybridisation of control (E) and sox3 morphant (F–H) embryos viewed dorsally showing otic vesicles marked by the expression of pax2a again showing reduced (F), split (arrows, G) or absent (H) vesicles. (I, J) Lateral view showing placodal expression of ngn1 in control (I) and sox3 morphant embryos (J, 27/42). (K, L) Lateral view showing expression of phox2a in the epibranchial placodes of control (K) and sox3 morphant (L, 37/51) embryos. Expression of both ngn1 and phox2a is severely disrupted in the placodes of morphant embryos (J, L). ad, anterodorsal lateral line; av, anteroventral lateral line; f, facial; o/g, octaval/statoacoustic/glossopharyngeal.

Expression Data
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-5

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 320(1), Dee, C.T., Hirst, C.S., Shih, Y.H., Tripathi, V.B., Patient, R.K., and Scotting, P.J., Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm, 289-301, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.