FIGURE

Fig. 6

ID

ZDB-FIG-080522-19

Publication

Hashimoto et al., 2000 - Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation

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Fig. 6

Overexpression of dkk1 rescues the phenotypes of boz^m168 mutants. (A) boz^m168 homozygous embryos did not have anterior neuroectoderm structures (b, left) or notochord (b, right). boz^m168 homozygous (a) or wild-type embryos (c) injected with 5 pg of dkk1 RNA had enlarged separated eyes and anterior neuroectoderm structures (left panels), and notochord (right panels). Animal pole views for head region (left panels) and lateral views for trunk (right panels). (B) ntl expression was detected in dorsal midline at the tail-bud stage in the boz^m168 heterozygous embryos (a), but ntl expression domain stayed in the tail bud and ntl transcripts were not detected in dorsal midline in boz^m168 homozygous embryos (b). Shorter and wider ntl expression domain was detected in boz^m168 heterozygous (c) and homozygous (d) embryos injected with dkk1 RNA, compared to the heterozygous uninjected embryos (a).

Expression Data

Gene:	tbxta
Fish:	dharma^m168/m168 (AB) dharma^m168/+ (AB)
Anatomical Terms:	axial mesoderm tail bud
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dharma^m168/m168 (AB)
Observed In:	eye forebrain notochord
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 217(1), Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T., Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation, 138-152, Copyright (2000) with permission from Elsevier. Full text @ Dev. Biol.