FIGURE

Fig. 7

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ZDB-FIG-080522-20
Publication
Hashimoto et al., 2000 - Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation
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Fig. 7

Overexpression of dkk1 promotes anterior neuroectoderm development in the absence of dorso-anterior mesendoderm. (A) Embryos injected with 5 pg of antivin (atv) RNA lack most of mesoderm and endoderm except tail region, but contained a cyclopic eye (a). Embryos coinjected with 5 pg of atv and 20 pg of dkk1 RNA displayed enlarged head structures (b) with an enlarged cyclopic eye (c) which expresses six3 in a higher level (e), compared to an eye in the atv RNA-injected embryos (d). (B) Expression of gsc in the embryonic shield was not detected in either the atv RNA-injected embryos (a) or the atv and dkk1 RNA-injected embryos (b), compared to uninjected shield-stage embryos (c). Animal pole views, dorsal to the right. However, expression of six3 at 9 hpf was expanded in the atv and dkk1 RNA-injected embryos (e, g), compared to the atv RNA-injected embryos (d, f). (d, e) Lateral views, dorsal to the right. (f, g) Dorso-anterior views.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 217(1), Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T., Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation, 138-152, Copyright (2000) with permission from Elsevier. Full text @ Dev. Biol.