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ZFIN ID: ZDB-FIG-080514-53
Willot et al., 2002 - Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Developmental Biology   241(1):59-78 Full text @ Dev. Biol.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: 5-9 somites to Prim-5

Fig. 8 Overexpression of admp or tr-admp RNA and in snailhouse. admp RNA (600 pg) or tr-admp RNA (600 pg) was injected at the one-cell stage into the progeny of snailhouse heterozygous fish. (A–C) Phenotypes were observed live after 1 day of development or (D–I) after in situ hybridization. (D–F) pax 2.1 and myo D in dark blue, hgg1 and krox 20 in red at the five- to seven-somite stage. (G–I) her5 and fkd6 in dark blue, hgg1, krox 20, and ntl in red at the six-somite stage. (A) Uninjected, -/+ or +/+ embryo. (B) Uninjected, snailhouse C4 phenotype. (C) admp-injected snailhouse mutant, C2 phenotype. (B, C) The eye is reduced in (C), compare with (B) (arrowhead). (D, G) Uninjected, -/+ or +/+ embryo. (E) Uninjected, snailhouse C4 phenotype. (F) admp-injected homozygous snailhouse embryo, C2 phenotype. (H) Uninjected, snailhouse C4 phenotype. The neural crest is expanded. (I) tr-admp-injected homozygous snailhouse embryo, C5 phenotype.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
bmp7aty68a/ty68a standard conditions 5-9 somites neural crest increased size, abnormal
5-9 somites somite increased width, abnormal
5-9 somites tail bud mislocalised posteriorly, abnormal
5-9 somites whole organism shape, abnormal
5-9 somites whole organism wholly dorsalized, abnormal
Prim-5 whole organism wholly dorsalized, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 241(1), Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y.-L., Postlethwait, J.H., Mullins, M., Rosa, F., and Peyriéras, N., Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula, 59-78, Copyright (2002) with permission from Elsevier. Full text @ Dev. Biol.