FIGURE

Fig. S2

ID

ZDB-FIG-080508-11

Publication

Schenck et al., 2008 - The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

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Fig. S2

Appl2 localization and recruitment to Rab5C-labeled endosomes.
Zebrafish embryos were injected with 100 pg appl2-Venus mRNA at 1 cell stage and with 50 pg CFP-Rab5C mRNA into single blastomeres at 16-cell stage, fixed and imaged at 50% epiboly stage. A single confocal section is shown, represented proteins are indicated. Draq5 and phalloidin staining highlight nuclei and cell margins. Note that the distribution of ubiquitously expressed Appl2-Venus is altered in all CFP-Rab5C co-expressing cells. Bigger and brighter structures are observed. Scale bar: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 133(3), Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M., and Zerial, M., The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development, 486-497, Copyright (2008) with permission from Elsevier. Full text @ Cell