FIGURE

Fig. 3

ID

ZDB-FIG-080505-8

Publication

Snelson et al., 2008 - Tbx2b is required for the development of the parapineal organ

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Fig. 3

Disruption of parapineal formation in fby mutant zebrafish larvae. (A-F) Dorsal and (G,H) frontal views of the epithalamus of (A,C,E,G) WT and (B,D,F,H) fby mutant larvae. (A,B) At 24 hpf, the pineal complex anlage labeled with otx5 (blue) appeared similar in WT embryos (A) and fby mutants (B). (C,D) However, by 34 hpf, when a parapineal was apparent in WT embryos (C), no parapineal organ developed in fby mutants (D). Arrowhead in C indicates the emerging parapineal organ. (E,G) By 4 dpf, WT larvae had a left-sided parapineal organ (arrowheads) and more cells expressed lov (red) in the left habenula. (F,H) In fby mutant larvae, no left-sided parapineal organ was apparent; rather, otx5-expressing cells were found below the pineal organ. The number of lov-expressing cells in the left habenula was reduced compared with WT. Scale bars: 25 μm.

Expression Data

Genes:	kctd12.1 otx5
Fish:	WT tbx2b^c144/c144 (AB)
Anatomical Terms:	epiphysis habenula parapineal organ pineal complex
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx2b^c144/c144 (AB)
Observed In:	epithalamus development parapineal organ pineal complex
Stage Range:	Prim-15 to Day 4

Phenotype Detail

Acknowledgments

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