ZFIN ID: ZDB-FIG-071219-19
Yee et al., 2007 - Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biology   5(11):e312 Full text @ PLoS Biol.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 1 The slj Mutation Disrupts Intestinal and Exocrine Pancreas Development (A–D) Lateral views of 5-dpf wild-type (A) and slj (B) larvae, with representative histological cross-sections (C and D). The slj intestine is small, thin walled, and lacks folds (arrows, [A and B]) compared with wild type, and the slj terminal branchial arches are reduced (arrowheads). The columnar morphology and apical microvilli of the slj epithelium are less developed than in wild-type larvae (C and D); an asterisk (*) indicates the intestinal lumen. (E and F) The size of the slj liver (indicated by red asterisk in [A] and [B]) and the retinae (arrows, [E and F], dorsal view) are also reduced. (G and H) Although exocrine tissue is well developed in wild-type embryos (arrowhead in [G]), it is markedly reduced or absent in slj embryos (H); asterisks indicate intestine. By contrast, the slj and wild-type pancreatic islets are of comparable size (arrows).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
polr3bm74/m74 standard conditions Day 5 exocrine pancreas decreased size, abnormal
Day 5 intestinal epithelium decreased size, abnormal
Day 5 intestinal epithelium decreased thickness, abnormal
Day 5 intestinal epithelium flat, abnormal
Day 5 intestinal epithelium microvillus decreased size, abnormal
Day 5 intestine decreased size, abnormal
Day 5 liver decreased size, abnormal
Day 5 pharyngeal arch decreased size, abnormal
Day 5 retina decreased size, abnormal
Acknowledgments:
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