FIGURE

Fig. 5

ID

ZDB-FIG-070921-8

Publication

Nambiar et al., 2007 - Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration

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Fig. 5

tri/vangl2 is able to rescue extension defects and tangential migration of hindbrain branchiomotor neurons in col mutant embryos. Overexpression of tri/vangl2 in col mutants (B and D) is able to rescue the stunted trunk development and broad notochords observed in uninjected col mutants (A and C). Facial (nVII) hindbrain motor neurons labeled by islet1 expression are positioned ectopically in r4 in col mutants at 56 hpf (F) compared to wildtype (E). Overexpression of tri/vangl2 restores tangential migration of these neurons into r6 and r7 (G) as in wildtype siblings (E). nV neurons are positioned correctly in r2 in tri/vangl2 injected (G) and uninjected (F) col mutants.

Expression Data

Gene:	isl1a
Fish:	WT hdac1^b382/b382
Anatomical Terms:	rhombomere 2 rhombomere 4 rhombomere 6 rhombomere 7
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^b382/b382
Observed In:	facial nerve motor nucleus motor neuron
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.