|ZFIN ID: ZDB-FIG-070821-19|
Fig. 8 Cell adhesion between the deep cells and the enveloping layer is disrupted in cdh1 morphant embryos. Wild-type control (wt, A, C, E, G) and cdh1 morphant embryos (MO) embryos (B, D, F, H) were fixed at 8.5 hpf (80% epiboly for the wild-type) and subjected to electron microscopic analysis. Lateral regions. Adhesion between the enveloping layer (EVL) and the deep cells (DCs) was detected in the wild-type control embryos (indicated by arrows in A, C, E), but was severely affected in the cdh1 morphant embryos (arrows in B, D, F). In contrast, the adhesions between the EVL cells (arrowheads in A, C, D) or between the DCs (arrowheads in G, H) were not significantly affected in the cdh1 morphant embryos, compared with the wild-type control embryos.
|WT + MO6-cdh1||standard conditions||75%-epiboly||cell-cell adhesion involved in gastrulation decreased process quality, abnormal|
|75%-epiboly||DEL detached from EVL, abnormal|
ZFIN wishes to thank the journal Mechanisms of Development for permission to reproduce figures from this article.
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Reprinted from Mechanisms of Development, 122(6), Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M., E-cadherin is required for gastrulation cell movements in zebrafish, 747-763, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.