FIGURE

Fig. 8

ID

ZDB-FIG-070813-39

Publication

Miller et al., 2007 - mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish

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Fig. 8

mef2ca activates dlx5a, dlx6a, and dlx4b but represses dlx3b. Lateral views of expression of dlx2a (A, B), dlx5a (C, D), dlx6a (E, F), dlx3b (G, H) and dlx4b (I, J) in wild-type (A, C, E, G, I) and mef2ca mutant (B, D, F, H, J) heads of 30 hpf zebrafish embryos. (A, B) mef2ca mutants have no detectable alteration in dlx2a expression, which is expressed throughout pharyngeal arch CNC. (C–F) Expression of both dlx5a and dlx6a, in ventral and intermediate CNC in wild-types, is reduced in mef2ca mutants. (G, H) dlx3b expression is ectopically expressed in dorsal arch CNC of mef2ca mutants (arrows). In G-H, first pharyngeal pouch is outlined. (I, J) In contrast, dlx4b expression, restricted to ventral arch CNC, is largely undetectable in mef2ca mutants. The first two arches are numbered. Scale bar: 50 μM.

Expression Data

Genes:	dlx2a dlx3b dlx4b dlx5a dlx6a
Fish:	WT mef2ca^b1086/b1086
Anatomical Term:	pharyngeal arch
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 308(1), Miller, C.T., Swartz, M.E., Khuu, P.A., Walker, M.B., Eberhart, J.K., and Kimmel, C.B., mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish, 144-157, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.