Gene
dlx4b
- ID
- ZDB-GENE-990415-50
- Name
- distal-less homeobox 4b
- Symbol
- dlx4b Nomenclature History
- Previous Names
-
- dlx7
- fj03c01
- wu:fj03c01
- zgc:109858
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic viscerocranium morphogenesis; sensory organ development; and trigeminal nerve development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in orofacial cleft 15. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; nervous system; pharyngeal arch; and splanchnocranium. Orthologous to human DLX4 (distal-less homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 31 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109858 (12 images)
- eu510 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
orofacial cleft 15 | Alliance | ?Orofacial cleft 15 | 616788 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000047 | Helix-turn-helix motif |
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain | IPR001356 | Homeodomain |
Domain | IPR020479 | Homeodomain, metazoa |
Family | IPR050460 | Distal-less homeobox transcription factors |
Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
Protein | Length | Distal-less homeobox transcription factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:Q98878
|
254 |
Interactions and Pathways
No data available
Plasmids
No data available