Gene

dlx4b

ID
ZDB-GENE-990415-50
Name
distal-less homeobox 4b
Symbol
dlx4b Nomenclature History
Previous Names
  • dlx7
  • fj03c01
  • wu:fj03c01
  • zgc:109858
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic viscerocranium morphogenesis; sensory organ development; and trigeminal nerve development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in orofacial cleft 15. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; nervous system; pharyngeal arch; and splanchnocranium. Orthologous to human DLX4 (distal-less homeobox 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Wu et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlx4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 15 Alliance ?Orofacial cleft 15 616788
Associated With dlx4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q98878 254
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations