Gene
dlx4b
- ID
- ZDB-GENE-990415-50
- Name
- distal-less homeobox 4b
- Symbol
- dlx4b Nomenclature History
- Previous Names
-
- dlx7
- fj03c01
- wu:fj03c01
- zgc:109858
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic viscerocranium morphogenesis; sensory organ development; and trigeminal nerve development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; nervous system; pharyngeal arch; and splanchnocranium. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 31 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109858 (12 images)
- eu510 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
orofacial cleft 15 | Alliance | ?Orofacial cleft 15 | 616788 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000047 | Helix-turn-helix motif |
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain | IPR001356 | Homeodomain |
Domain | IPR020479 | Homeodomain, metazoa |
Family | IPR050460 | Distal-less homeobox transcription factors |
Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
Protein | Length | Distal-less homeobox transcription factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:Q98878
|
254 |
Interactions and Pathways
No data available
Plasmids
No data available