FIGURE

Fig. 5

ID

ZDB-FIG-060912-11

Publication

Kazakova et al., 2006 - A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes

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Fig. 5

PLL phenotype of nls and nof mutants. (A) 5 dpf nls mutant fish. Note mbp expression in the anterior lateral line (arrows) but absent from the PLL. (B) PLL nerve (arrow) of nls mutant 5 dpf stained with anti-acetylated tubulin. In the wild type, axons branch off ventrally at intervals to innervate individual neuromeres (arrowhead) but no such branching is seen in the mutant. (C, D) 5 dpf nof mutant fish. The nof phenotype shows variable expressivity and in some mutants mpb is expressed on one side only (arrow) as shown in panel D. Note normal mbp expression in the PLL on the left side (arrow). (E, F) Plp1b expression in nls mutant (E) and wild type (F) fish. Plp1b is detectable on both sides in the wild type and on one side of the nls mutant (arrow). (G. H) Electron micrographs of the PLL in nls mutant fish. Note loosely wrapped ensheathment by myelin (arrows) of the large diameter axons. Scale bars in panels B, E and F, 10 μm; in inset in panel B, 5 μm; in panel G 1 μm; in panel H, 200 nm.

Expression Data

Genes:	mbpa plp1b
Fish:	WT aldh1a2^i26/i26 aldh1a2^u11/u11
Anatomical Terms:	anterior lateral line posterior lateral line posterior lateral line anatomical side
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh1a2^i26/i26
Observed In:	axonogenesis involved in innervation posterior lateral line nerve dendrite posterior lateral line nerve development
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 297(1), Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K., A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes, 1-13, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.