FIGURE

Fig. 2

ID

ZDB-FIG-060912-8

Publication

Kazakova et al., 2006 - A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes

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Fig. 2

PLL phenotype of doc and igu mutants. (A, B) Mbp expression (arrow) in 5 dpf larvae homozygous mutant for doc and igu respectively. Expression is restricted to the anteriormost section of the PLL. (C, D) Anti-acetylated tubulin staining (arrow) of PLL axons in panel C doc and panel D igu mutants. A PLL nerve extends to the posterior segments (arrows) of the fish in both mutants. (E, F) Electronmicrographs showing a transverve section of the rostral (mbp expressing) PLL in doc mutants. Axons ensheathed by loosely wrapped myelin (arrows) are clearly present in the mutant nerve. Scale bars in panels A and C, 5 μm; in panels B and D, 10 μm; in panel E, 1 μm; in panel F, 200 nm.

Expression Data

Gene:	mbpa
Fish:	doc^tt258/tt258 dzip1^tm79a/tm79a
Anatomical Term:	posterior lateral line anterior-most region
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	doc^tt258/tt258 dzip1^tm79a/tm79a
Observed In:	axon extension myelinating Schwann cell posterior lateral line nerve axon
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 297(1), Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K., A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes, 1-13, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.