FIGURE

Fig. 4

ID

ZDB-FIG-060609-2

Publication

Connors et al., 2006 - Temporal and spatial action of Tolloid (Mini fin) and Chordin to pattern tail tissues

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Fig. 4

Overexpression of tolloid phenocopies the chordino mutant. A Tg(hsp70:tld) embryo heat-shocked during and after gastrulation to remove Chd activity (A) can phenocopy din/chd mutants (B). Eye and head size is reduced, the blood increased (arrow), and the tail fins duplicated (arrowhead). Dorsal-anterior views of a representative 7-somite stage non-transgenic mfn embryo (N = 37) (C), transgenic mfn embryo (N = 42) (D), or din homozygote (E) stained for myoD, krox20, gata1, and pax2.1. R3 and R5 refer to rhombomeres 3 and 5, respectively. (F–H) More posterior dorsal views of embryos shown in panels (C–E). Arrows indicate smaller somites, and arrowheads indicate more laterally located pronephric and blood precursor domains in transgenic and din mutants.

Expression Data

Genes:	egr2b gata1a myod1 pax2a
Fish:	tll1^{tm124a/tm124a} (TU) chrd^unspecified
Condition:	heat shock
Anatomical Terms:	lateral plate mesoderm midbrain hindbrain boundary neural rod presumptive rhombomere 3 presumptive rhombomere 5 somite
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 293(1), Connors, S.A., Tucker, J.A., and Mullins, M.C., Temporal and spatial action of Tolloid (Mini fin) and Chordin to pattern tail tissues, 191-202, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.