FIGURE

Fig. 2

ID

ZDB-FIG-060601-2

Publication

Davidson et al., 2006 - The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis

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Fig. 2

Expression of hox genes, scl, and dra in cdx-deficient embryos. (A) Whole mount in situ hybridizations showing transcripts for hoxb5a, hoxb7a, and hoxa9a in cdx-deficient embryos and wild-type controls at the 10-somite stage. The extent of hoxb5a staining in the somites is indicated with a bracket. Arrows mark the anterior expression boundaries of hoxb7a and hoxa9a in the paraxial mesoderm. Dorsal views are shown, centered on the mid-trunk of flatmounted embryos, with anterior to the left. (B) Expression of scl and dra in cdx-deficient embryos and wild-type controls at the 5- and 15-somite stages. Note the cdx gene dosage effect on scl- and dra-expressing intermediate cell mass (ICM) precursor cells but not on rostral blood island (RBI)-derived cells. Presumptive angioblasts of the rostral ICM are indicated with a bracket and appear expanded in cdx4^−/− and cdx1a^mo;cdx4^−/− embryos at the 15-somite stage. Flatmounted embryos are shown in dorsal views with anterior to the left.

Expression Data

Genes:	drl hoxa9a hoxb5a hoxb7a tal1
Fish:	WT cdx4^{tv205c/tv205c} cdx4^{tv205c/tv205c} + MO2-cdx1a
Knockdown Reagent:	MO2-cdx1a
Anatomical Terms:	intermediate cell mass of mesoderm paraxial mesoderm posterior lateral mesoderm rostral blood island somite somite 2 somite 3 somite 4 somite 5 somite 6 somite 7 somite 8 somite 9 somite 10 tail bud
Stage Range:	5-9 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 292(2), Davidson, A.J., and Zon, L.I., The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis, 506-518, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.