ZFIN ID: ZDB-FIG-060303-9
Milan et al., 2006 - Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (Cambridge, England)   133(6):1125-1132 Full text @ Development
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 5 Endothelin 1 is not required for AV conduction tissue development. (A) Representative images of wild-type and endothelin 1 morphant fish. endothelin 1 morphants fail to develop structures derived from the pharyngeal arches, including the mandible. (B) endothelin 1 morphant fish develop normal AV conduction block on treatment with terfenadine at 48 hpf. Inset of contemporaneous recordings of atrial and ventricular contraction using intensity-time plots from regions over the respective chambers in an endothelin 1 morphant embryo demonstrating 1:1 AV conduction. (C) endothelin 1 morphant fish develop a normal AV conduction delay as seen in this calcium activation map of a single cardiac cycle at 48 hpf. Isochronal lines (50 mseconds) obtained by fluorescence microscopy are superimposed on a maximum intensity projection image.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-edn1 standard conditions Long-pec cardiac conduction rate, normal
Long-pec pharyngeal system development disrupted, abnormal
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development