ZFIN ID: ZDB-FIG-060303-9
Milan et al., 2006 - Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (Cambridge, England)   133(6):1125-1132 Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 5 Endothelin 1 is not required for AV conduction tissue development. (A) Representative images of wild-type and endothelin 1 morphant fish. endothelin 1 morphants fail to develop structures derived from the pharyngeal arches, including the mandible. (B) endothelin 1 morphant fish develop normal AV conduction block on treatment with terfenadine at 48 hpf. Inset of contemporaneous recordings of atrial and ventricular contraction using intensity-time plots from regions over the respective chambers in an endothelin 1 morphant embryo demonstrating 1:1 AV conduction. (C) endothelin 1 morphant fish develop a normal AV conduction delay as seen in this calcium activation map of a single cardiac cycle at 48 hpf. Isochronal lines (50 mseconds) obtained by fluorescence microscopy are superimposed on a maximum intensity projection image.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-edn1 standard conditions Long-pec cardiac conduction rate, normal
Long-pec pharyngeal system development disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development