ZFIN ID: ZDB-FIG-050725-10
Cha et al., 2005 - Cyclooxygenase-1 signaling is required for vascular tube formation during development. Developmental Biology   282(1):274-283 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Prim-5

Fig. 7 cox1-MO causes posterior mesoderm defect similar to indomethacin-induced phenotype. Compared to uninjected wild-type (A), injection of 8 ng cox1-MO (B) specifically disrupted posterior mesoderm organs at 1 day, including enlarged nephric duct and distended posterior vasculature (B, arrow). Staining with pax2.1 shows increased pronephric duct size in the posterior region (D). As the embryos develop, the increased staining correlates to increase in posterior nephric duct size at day 2 (H, arrow) and day 3 (I, arrow), compared to wild-type (E, F).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
pax2a WT standard conditions Prim-5 pronephric duct ISH
WT + MO1-ptgs1 standard conditions Prim-5 pronephric duct ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 282(1), Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N., Cyclooxygenase-1 signaling is required for vascular tube formation during development, 274-283, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.