ZFIN ID: ZDB-FIG-050615-2
Elworthy et al., 2005 - Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mechanisms of Development   122(5):659-669 Full text @ Mech. Dev.
Anatomical Term:
Stage: Prim-5

Fig. 8 Widespread defects in crestin expression in sox10 mutants extend to premigratory stages of neural crest development. Lateral views of head and trunk of 24 hpf wild-type (A) and sox10 mutant (B) zebrafish to show expression of crestin. Whilst in wild-types (A) crestin is strongly expressed in premigratory neural crest cells (asterisk) and in neural crest cells migrating on the medial pathway (large arrow), expression in these sites is dramatically reduced in sox10 mutants (B). In contrast, expression in neural crest cells in the branchial arch streams (arrowhead) is unaffected (A, compare B). A few cells on the medial pathway with relatively normal crestin expression levels in sox10 mutants (small arrow, A) may represent sensory neuron precursors (see Kelsh and Eisen (2000)).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
crestin WT standard conditions Prim-5 neural crest ISH
sox10m618/m618(AB) standard conditions Prim-5 neural crest ISH
Antibody Labeling Details No data available
Phenotype Details No data available
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Reprinted from Mechanisms of Development, 122(5), Elworthy, S., Pinto, J.P., Pettifer, A., Cancela, M.L., and Kelsh, R.N., Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent, 659-669, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.