FIGURE

Fig. 5

ID

ZDB-FIG-050323-29

Publication

Waxman et al., 2004 - Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes

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Fig. 5

dpr2 morphants phenocopy strabismus/trilobite (stbm) morphants, and functionally interact with stbm and wnt11/silberblick. (A) dpr2 morphants (middle-injected with 7.5 ng dpr2 MO) phenocopy stbm morphants (right-injected with 3 ng). Arrow indicates flattened, non-chevron-shaped somite. Arrowhead indicates narrowed eyes. (B) Scoring of embryos that were co-injected with suboptimal doses of stbm and dpr2 MOs. 0, wild type; 1, moderate CE defects; 2, severe CE defects. (C) Percentage of embryos injected with MOs exhibiting phenotype. (D) Scoring of cyclopia index of embryos co-injected with dpr2 MO and wnt11 MO (a-f). dpr2 MO (normal dose, g,h). 0, wild type; 1, narrowing of the eyes; 2, fusion of the lens. (E) Percentage of embryos injected displaying respective phenotypes. Suboptimal (hypomorphic) dose of dpr2 MO is 3 ng, stbm MO is 0.4 ng and wnt11 MO is 1.5 ng. All injections were balanced with control MO. The numbers in brackets indicate the numbers of embryos used.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dact2 WT + MO1-vangl2 WT + MO1-wnt11f2 WT + MO1-dact2 + MO1-vangl2 WT + MO1-dact2 + MO1-wnt11f2
Knockdown Reagents:	MO1-dact2 MO1-vangl2 MO1-wnt11f2
Observed In:	convergent extension involved in axis elongation eye somite whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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