CRISPR

CRISPR13-foxc1a

ID
ZDB-CRISPR-200102-2
Name
CRISPR13-foxc1a
Previous Names
None
Target
Sequence
5' - CCGCCGCCGGAGGGGGGTACACC - 3'
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
None
Genome Resources
None
Target Location
Constructs
No data available
Genomic Features
Genomic Feature Affected Genomic Regions
ua1017 foxc1a
Expression
Gene expression in Wild Types + CRISPR13-foxc1a
No data available
Phenotype
Phenotype resulting from CRISPR13-foxc1a
No data available
Phenotype of all Fish created by or utilizing CRISPR13-foxc1a
Phenotype Fish Conditions Figures
aortic arch myl9a expression decreased amount, abnormal foxc1aua1017/ua1017 standard conditions Fig. 8 with image from Whitesell et al., 2019
heart edematous, abnormal foxc1aua1017/ua1017 standard conditions Fig. S11 with image from Whitesell et al., 2019
vascular associated smooth muscle cell foxc1b expression decreased amount, abnormal foxc1aua1017/ua1017 standard conditions Fig. 8 with image from Whitesell et al., 2019
pericyte pdgfrb expression decreased amount, abnormal foxc1aua1017/ua1017 standard conditions Fig. 8 with image from Whitesell et al., 2019
vascular associated smooth muscle cell foxc1a expression decreased amount, abnormal foxc1aua1017/ua1017 standard conditions Fig. 8 with image from Whitesell et al., 2019
vascular associated smooth muscle cell acta2 expression decreased amount, abnormal foxc1aua1017/ua1017 standard conditions Fig. 8 with image from Whitesell et al., 2019
whole organism col1a1a expression decreased amount, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 7 with image from Hawkey-Noble et al., 2022
whole organism col11a2 expression decreased amount, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 7 with image from Hawkey-Noble et al., 2022
vertebra ossification absent process, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 6 with image from Hawkey-Noble et al., 2022
head deformed, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
determination of heart left/right asymmetry disrupted, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
brain hemorrhagic, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
opercular flap ossification decreased process quality, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
pericardium edematous, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
whole organism hpxa expression decreased amount, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 7 with image from Hawkey-Noble et al., 2022
lateral plate mesoderm lft2 expression spatial pattern, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 6 with image from Chrystal et al., 2021
pharyngeal arch 1 ossification decreased process quality, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
heart myl7 expression spatial pattern, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
eye decreased size, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
pharyngeal arch 2 ossification decreased process quality, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
whole organism matn1 expression decreased amount, abnormal foxc1aua1017/ua1017 (AB) standard conditions Figure 7 with image from Hawkey-Noble et al., 2022
ventral aorta decreased length, abnormal foxc1aua1017/ua1017; ca7Tg/+; ci5Tg/+ standard conditions Fig. 8 with image from Whitesell et al., 2019
heart edematous, abnormal foxc1aua1017/ua1017; foxc1bua1018/+ standard conditions Fig. S11 with image from Whitesell et al., 2019
ventral aorta vascular associated smooth muscle cell decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/+; ca7Tg/+; ci5Tg/+ standard conditions Fig. 8 with image from Whitesell et al., 2019
aortic arch myl9a expression decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. 8 with image from Whitesell et al., 2019
heart edematous, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. S11 with image from Whitesell et al., 2019
vascular associated smooth muscle cell foxc1b expression decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. 8 with image from Whitesell et al., 2019
pericyte pdgfrb expression decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. 8 with image from Whitesell et al., 2019
vascular associated smooth muscle cell foxc1a expression decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. 8 with image from Whitesell et al., 2019
vascular associated smooth muscle cell acta2 expression decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 standard conditions Fig. 8 with image from Whitesell et al., 2019
heart myl7 expression spatial pattern, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
brain ventricular system swollen, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
head deformed, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
determination of pancreatic left/right asymmetry disrupted, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
determination of heart left/right asymmetry disrupted, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
brain hemorrhagic, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
pericardium edematous, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
Figure 2 with image from Chrystal et al., 2021
opercular flap ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
determination of liver left/right asymmetry disrupted, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
lateral plate mesoderm lft2 expression spatial pattern, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 6 with image from Chrystal et al., 2021
pancreas foxa3 expression spatial pattern, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
pharyngeal arch 1 ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
eye decreased size, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 2 with image from Chrystal et al., 2021
pharyngeal arch 2 ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
liver foxa3 expression spatial pattern, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018 (AB) standard conditions Figure 3 with image from Chrystal et al., 2021
ventral aorta vascular associated smooth muscle cell decreased amount, abnormal foxc1aua1017/ua1017; foxc1bua1018/ua1018; ca7Tg/+; ci5Tg/+ standard conditions Fig. 8 with image from Whitesell et al., 2019
pharyngeal arch 2 ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
cranial cartilage ossification absent process, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 6 with image from Hawkey-Noble et al., 2022
vertebra ossification absent process, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 6 with image from Hawkey-Noble et al., 2022
opercular flap ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
pericardium edematous, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
pharyngeal arch 1 ossification decreased process quality, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 4 with image from Hawkey-Noble et al., 2022
coelom edematous, abnormal foxc1aua1017/ua1017; foxl1nfl1/nfl1 (AB) standard conditions Figure 6 with image from Hawkey-Noble et al., 2022
Citations