FIGURE

Figure 3

ID

ZDB-FIG-210301-144

Publication

Chrystal et al., 2021 - The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning

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Figure 3

Decreased dosages of foxc1 result in multi-organ situs defects. (A) In situ hybridization with myl7 at 48 hpf revealed aberrant cardiac situs (O-loop (green); L-loop (red)) compared with normal D-loop (blue). The prevalence of aberrant situs is increased in foxc1a, foxc1b, and double homozygotes (* p = 0.016, * 0.036, *** < 0.001 respectively, Fisher’s exact test) when compared to WT siblings. (B) At the same stage, the normal arrangement (solitus, blue) of the gut is left-sided liver (l) and right-sided pancreas (p); however, the incidence of abnormal (ambiguous, green) gut situs was significantly greater in double homozygotes (** p = 0.003, Fisher’s exact test).

Expression Data

Genes:	foxa3 myl7
Fish:	AB foxc1a^{ua1017/ua1017} (AB) foxc1b^{ua1018/ua1018} (AB) foxc1a^{ua1017/ua1017}; foxc1b^{ua1018/ua1018} (AB)
Anatomical Terms:	heart liver pancreas
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxc1a^{ua1017/ua1017} (AB) foxc1b^{ua1018/ua1018} (AB) foxc1a^{ua1017/ua1017}; foxc1b^{ua1018/ua1018} (AB)
Observed In:	determination of heart left/right asymmetry determination of liver left/right asymmetry determination of pancreatic left/right asymmetry heart liver pancreas
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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