ZFIN is now using GRCz12tu for Genomic Data
Gene
th
- ID
- ZDB-GENE-990621-5
- Name
- tyrosine hydroxylase
- Symbol
- th Nomenclature History
- Previous Names
-
- th1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in neuron projection; perinuclear region of cytoplasm; and synapse. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; heroin dependence; hypertension; movement disease (multiple); and obesity. Orthologous to human TH (tyrosine hydroxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 330 figures from 181 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive Segawa syndrome | Alliance | Segawa syndrome, recessive | 605407 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Conserved_site | IPR021164 | Tyrosine hydroxylase, conserved site |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
| Domain | IPR049321 | Tyrosine 3-monooxygenase-like, ACT domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005962 | Tyrosine 3-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like | Tyrosine 3-monooxygenase-like, ACT domain | Tyrosine hydroxylase, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJW5 | InterPro | 489 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000002329 (1) | Havana | 1,226 nt | ||
| mRNA |
th-201
(1)
|
Ensembl | 1,470 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| ab8-th | Rabbit |
|
1 | ||||
| ab7-th | IgY | Chicken |
|
3 | |||
| Ab5-th | monoclonal | IgG2a , k | Mouse |
|
Vector Laboratories
|
3 | |
| Ab3-th | monoclonal | IgG1 , k | Mouse |
|
Millipore
Antibodies-online.com |
120 | |
| Ab4-th | polyclonal | Rabbit |
|
Millipore
|
53 | ||
| Ab1-th | monoclonal | IgG1 | Mouse |
|
ImmunoStar, Inc.
|
51 | |
| Ab2-th | polyclonal | Rabbit |
|
Pel-Freez Biologicals
|
15 | ||
| Ab6-th | polyclonal | Rabbit |
|
20 |
Plasmids
- Genome Browsers