Gene

cyp19a1a

ID

ZDB-GENE-990415-43

Name

cytochrome P450, family 19, subfamily A, polypeptide 1a

Symbol

cyp19a1a Nomenclature History

Previous Names

ar1
cyp19
CYP19a1 (1)
cyp19a (1)
cypXIX
aromatase
etID309862.18 (1)
ovarian aromatase (1)
P450aromA (1)
zgc:136541 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to localize to integral component of membrane. Used to study disorders of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Is expressed in several structures, including eye; female organism; granulosa cell; male organism; and reproductive system. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

84 figures from 59 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp19a1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aromatase excess syndrome	Alliance	Aromatase excess syndrome	139300
		Aromatase deficiency	613546

Associated With cyp19a1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
disorder of sexual development	cyp19a1a^{zf1031/zf1031} (AB)	standard conditions	Yin et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily