ZFIN ID: ZDB-GENE-990415-43
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1a
Gene Symbol: cyp19a1a
Sequence Ontology ID : SO:0000704

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Previous Names: ar1, cyp19, CYP19a1 (1), cyp19a (1), cypXIX, aromatase, etID309862.18 (1), ovarian aromatase (1), P450aromA (1), zgc:136541 (1)

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have heme binding activity, iron ion binding activity, and oxidoreductase activity; involved in several processes, including female gonad development, germ-line sex determination, and  ...
GENE EXPRESSION
All Expression Data: 62 figures from 39 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb158 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • ihb159 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • uc38 Small Deletion Unknown Frameshift, Premature Stop TALEN
    uc43 Indel Unknown Frameshift, Premature Stop TALEN
    umo5 Small Deletion Unknown Unknown TALEN
    umo6 Small Deletion Unknown Unknown CRISPR
    umo7 Indel Unknown Unknown CRISPR
    zf1031 Small Deletion Exon 3 Frameshift TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 9 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH cyp19a1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    aromatase excess syndrome Aromatase excess syndrome 139300
    Aromatase deficiency 613546
    DISEASE ASSOCIATED WITH cyp19a1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    sex development disorder cyp19a1azf1031/zf1031(AB) standard conditions Yin et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to estradiol (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • InterPro:IPR036396 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • EC:1.14.14.14 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA cyp19a1a-002 (1) 1673
    mRNA cyp19a1a-201 (1) 1862
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cyp19a1a
    MARKER RELATIONSHIPS
    cyp19a1aContained in: [BAC] CH211-165A16 (1) (order this)
    cyp19a1aEncodes: [cDNA] MGC:136541 (1) (order this), MGC:194465 (1), MGC:194471 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131154 (1) 1786bp
    Genomic GenBank:BX908722 (1) 166917bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q9I0 (1) 517aa
    Sequence Clusters UniGene:75765 (1)
    Sequence Information (all 31)
    OTHER cyp19a1a GENE PAGES
  • Alliance (1)
  • Gene:30390 (1)
  • VEGA:OTTDARG00000013418 (1)
  • ORTHOLOGY for cyp19a1a (Chr: 18)
    CITATIONS (239)