Gene

cyp19a1a

ID
ZDB-GENE-990415-43
Name
cytochrome P450, family 19, subfamily A, polypeptide 1a
Symbol
cyp19a1a Nomenclature History
Previous Names
  • ar1
  • cyp19
  • CYP19a1 (1)
  • cyp19a (1)
  • cypXIX
  • aromatase
  • etID309862.18 (1)
  • ovarian aromatase (1)
  • P450aromA (1)
  • zgc:136541 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have aromatase activity. Involved in several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to localize to endoplasmic reticulum. Is expressed in several structures, including eye; female organism; granulosa cell; male organism; and reproductive system. Used to study disorder of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
Genome Resources
Note
None
Expression
All Expression Data
72 figures from 47 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp19a1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aromatase excess syndrome Alliance Aromatase excess syndrome 139300
Aromatase deficiency 613546
Associated With cyp19a1a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450 superfamily
UniProtKB:Q1LV36 517
UniProtKB:Q9DG53 481
UniProtKB:Q98UC7 517
UniProtKB:A0A2R8Q9I0 517
UniProtKB:Q98SP3 68
UniProtKB:O42145 509
UniProtKB:Q9DG54 517
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB2-cyp19a1a polyclonal Rabbit
1
Ab1-cyp19a1a polyclonal IgG Rabbit
AnaSpec
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations