ZFIN ID: ZDB-GENE-980526-485

Gene Name:POU domain, class 5, transcription factor 1
Gene Symbol: pou5f1

Previous Names: gp9, gp-9, cb197(1) , pou2(1) , spg, wu:fd18d06, etID49452.21(1) , oct4, chunp6868, spiel-ohne-grenzen(1) , spiel ohne grenzen
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	14 figure(s) from 7 publications
Directly submitted expression data:	6 figure(s) (17 images) from Thisse et al., 2001 [cb197]
	2 figure(s) (4 images) from Rauch et al., 2003 [MGC:55202]
Wild Type Stages, Structures:	Blastula:Sphere (4.00h-4.33h) to Adult (90d-730d, breeding adult)
	hindbrain neural plate, midbrain neural keel ... (all 9)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   22 genotypes
Allele(s):   e68, e713, hi1757Tg, hi1940Tg, hi349Tg ... (all 10)

Phenotype: (current status)

Data:	26 figures from 5 publications
Observed in:	actin filament, axon, blastoderm, blastoderm cell, brain ... (all 43)

Knockdown reagents: MO1-pou5f1 (1) ,   MO2-pou5f1 (1) ,   MO3-pou5f1 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	positive regulation of transcription, DNA-dependent (more)
Cellular Component	nucleus
Molecular Function	sequence-specific DNA binding transcription factor activity (more)

All GO Terms (19)

Protein Families, Domains and Sites:

InterPro:IPR000327 (1) InterPro:IPR001356 (1) InterPro:IPR009057 (1) InterPro:IPR010982 (1) InterPro:IPR012287 (1) InterPro:IPR013847 (1) InterPro:IPR017970 (1)

PROSITE:PS00027 (1) PROSITE:PS00035 (1) PROSITE:PS00465 (1) PROSITE:PS50071 (1) PROSITE:PS51179 (1)

Pfam:PF00046 (1) Pfam:PF00157 (1)

Gene Product Description

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CONSTRUCTS WITH SEQUENCE FROM pou5f1:

Tg(-6.5pou5f1:EGFP)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

pou5f1 Contained in	[BAC] CH211-13C3 (1)    (order this)
pou5f1 Contains	[SNP] rs3729086 (1)
pou5f1 Encodes	[EST] cb197 (1)    (order this) , fd18d06 [STS] chunp6868 [cDNA] MGC:55202 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131112 (1)	2425 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX649363 (1)	196451 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZU11 (1)	472 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:258 (1)
All Sequence Information (17)

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OTHER  pou5f1  GENE / MARKER PAGES:

Entrez Gene:30333 (1)

Ensembl(Zv8):ENSDARG00000044774 (1)

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MAPPING INFORMATION:

LG:  21  Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	NT	CL	FC
Zebrafish	pou5f1	21
Human	POU5F1	6 (p21.31)	OMIM:164177 Entrez Gene:5460
Mouse	Pou5f1	17 (19.23 cM)	MGI:101893 Entrez Gene:18999
Orthology Details

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CITATIONS   (58)