Gene

lhx3

ID
ZDB-GENE-980526-131
Name
LIM homeobox 3
Symbol
lhx3 Nomenclature History
Previous Names
  • lim3
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in adenohypophyseal placode; nervous system; neural keel; and neural tube. Orthologous to human LHX3 (LIM homeobox 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
49 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lhx3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 3 221750
Associated With lhx3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR001781 Zinc finger, LIM-type
Domain IPR049593 LIM/homeobox protein Lhx3, LIM domain 1
Domain IPR049594 LIM/homeobox protein Lhx3/4-like, LIM domain 2
Family IPR050453 LIM/homeobox transcription factors
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain LIM/homeobox protein Lhx3/4-like, LIM domain 2 LIM/homeobox protein Lhx3, LIM domain 1 LIM/homeobox transcription factors Zinc finger, LIM-type
UniProtKB:A0A0G2KNU1
UniProtKB:Q90421 398
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab1-lhx3/4 polyclonal Rabbit
  • IHC
1
Ab3-lhx3 polyclonal Rabbit
  • IHC
1
ab1-lhx3 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations