Gene

lhx3

ID
ZDB-GENE-980526-131
Name
LIM homeobox 3
Symbol
lhx3 Nomenclature History
Previous Names
  • lim3
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Is expressed in adenohypophyseal placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX3 (LIM homeobox 3).
Genome Resources
Note
None
Expression
All Expression Data
48 figures from 31 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lhx3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 3 221750
Associated With lhx3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001781 Zinc finger, LIM-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Zinc finger, LIM-type
UniProtKB:A0A0G2KNU1
UniProtKB:Q90421 398
UniProtKB:O42286 374
UniProtKB:B3DH40 398
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab1-lhx3/4 polyclonal Rabbit
  • IHC
1
Ab3-lhx3 polyclonal Rabbit
  • IHC
1
ab1-lhx3 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations