ZFIN ID: ZDB-GENE-980526-131
Gene Name: LIM homeobox 3
Gene Symbol: lhx3    Nomenclature History

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Previous Name: lim3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in adenohypophyseal placode; nervous system; neural keel; and neural tube. Orthologous to human LHX3 (LIM homeobox 3).
Genome Resources: Alliance (1),  Gene:30455 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lhx3 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH lhx3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 3 221750
DISEASE ASSOCIATED WITH lhx3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ventral spinal cord interneuron specification (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001781 Zinc finger, LIM-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
ab1-lhx3/4 polyclonal Rabbit IHC 1
Ab3-lhx3 polyclonal Rabbit IHC 1
ab1-lhx3 polyclonal Rabbit IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lhx3 No data available
MARKER RELATIONSHIPS
lhx3 Encodes: [EST] eu264 (1)
[cDNA] MGC:193972 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131208 (1) 1369 nt
Genomic GenBank:AF031630 (1) 5155 nt
Polypeptide UniProtKB:B3DH40 (1) 398 aa
Sequence Information (all 20)
ORTHOLOGY for lhx3 ( Chr: 5 )
CITATIONS (82)