Gene
lhx3
- ID
- ZDB-GENE-980526-131
- Name
- LIM homeobox 3
- Symbol
- lhx3 Nomenclature History
- Previous Names
-
- lim3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in adenohypophyseal placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX3 (LIM homeobox 3).
- Genome Resources
-
- Alliance (1)
- Gene:30455 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu264 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypopituitarism | Alliance | Pituitary hormone deficiency, combined, 3 | 221750 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Zinc finger, LIM-type |
|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KNU1
|
|||||
|
UniProtKB:Q90421
|
398 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance