ZFIN ID: ZDB-GENE-060728-1
Gene Name: LIM homeobox 4
Gene Symbol: lhx4    Nomenclature History

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Previous Name: si:dkeyp-35f11.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Is expressed in adenohypophyseal placode; nervous system; spinal cord neural keel; and spinal cord neural tube. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX4 (LIM homeobox 4).
Genome Resources: Alliance (1),  Gene:571943 (1),  Ensembl(GRCz11):ENSDARG00000039458 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lhx4 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH lhx4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 4 262700
DISEASE ASSOCIATED WITH lhx4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ventral spinal cord interneuron specification (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lhx4-201 (1)    Ensembl 2627
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
ab1-lhx3/4 polyclonal Rabbit IHC 1
ab1-lhx4 polyclonal Rabbit IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lhx4 No data available
MARKER RELATIONSHIPS
lhx4 Contained in: [BAC] CH211-243A22 (1), DKEY-39N1 (1) (order this), DKEYP-35F11 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001122973 (1) 1176 nt
Genomic GenBank:CR381643 (1) 217745 nt Blast at MegaBLAST
Polypeptide UniProtKB:B0S5S7 (1) 391 aa
Sequence Information (all 14)
ORTHOLOGY for lhx4 ( Chr: 8 )
CITATIONS (20)