Gene
nts
- ID
- ZDB-GENE-091204-433
- Name
- neurotensin
- Symbol
- nts Nomenclature History
- Previous Names
-
- si:ch73-193m8.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable neuropeptide hormone activity. Predicted to be located in extracellular region and transport vesicle. Is expressed in GABAergic neurons and brain. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Levitas-Djerbi et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008055 | Neurotensin/neuromedin N |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Neurotensin/neuromedin N |
|---|---|---|---|
| UniProtKB:A0A0A7H8E2 | InterPro | 175 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:nts) |
|
| 1 | Levitas-Djerbi et al., 2019 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-193M8 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017352078 (1) | 1008 nt | ||
| Genomic | GenBank:CU928204 (2) | 125460 nt | ||
| Polypeptide | UniProtKB:A0A0A7H8E2 (1) | 175 aa |
- Spikol, E.D., Cheng, J., Macurak, M., Subedi, A., Halpern, M.E. (2024) Genetically defined nucleus incertus neurons differ in connectivity and function. eLIFE. 12:
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Levitas-Djerbi, T., Sagi, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2019) Neurotensin Enhances Locomotor Activity and Arousal, and Inhibits Melanin-Concentrating Hormone Signalings. Neuroendocrinology. 110(1-2):35-49
- Lopes, M.W., Sapio, M.R., Leal, R.B., Fricker, L.D. (2016) Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. PLoS One. 11:e0152905
- Herget, U., Ryu, S. (2015) Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish. Frontiers in Neuroanatomy. 9:2
- Levitas-Djerbi, T., Yelin-Bekerman, L., Lerer-Goldshtein, T., Appelbaum, L. (2015) The Hypothalamic Leptin-Neurotensin-Hypocretin Neuronal Networks in Zebrafish. The Journal of comparative neurology. 523(5):831-48
- Gutierrez-Triana, J., Herget, U., Lichtner, P., Castillo-Ramírez, L.A., Ryu, S. (2014) A vertebrate-conserved cis -regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response. BMC Developmental Biology. 14:41
- Herget, U., Wolf, A., Wullimann, M.F., and Ryu, S. (2014) Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. The Journal of comparative neurology. 522(7):1542-64
1 - 10 of 10
Show