Gene

pbx1b

ID
ZDB-GENE-070424-11
Name
pre-B-cell leukemia homeobox 1b
Symbol
pbx1b Nomenclature History
Previous Names
  • zgc:158824
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Is expressed in head. Orthologous to human PBX1 (PBX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pbx1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay Alliance Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay 617641
Associated With pbx1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR005542 PBX, PBC domain
Domain IPR008422 KN homeodomain
Family IPR050224 Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain KN homeodomain PBX, PBC domain Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:A0A8M9PM87 346
UniProtKB:A2VD48 429
UniProtKB:F1QSY5 429
UniProtKB:A0A8M9QFI5 433
UniProtKB:A0A8M9QAG1 350
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pbx polyclonal Rabbit
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations