Gene
ezrb
- ID
- ZDB-GENE-050803-1
- Name
- ezrin b
- Symbol
- ezrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; epiboly; and regulation of cilium assembly. Predicted to be located in several cellular components, including apical plasma membrane; cell cortex; and cell projection membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including anterior axial hypoblast; digestive system; hatching gland; nervous system; and prechordal plate. Orthologous to human EZR (ezrin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb567 (14 images)
- IMAGE:7140274 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6621 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14485 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14899 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23649 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa36988 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ezrb | N/A | (6) |
| MO2-ezrb | N/A | (8) |
| TALEN1-ezrb | Zhou et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | ERM family, FERM domain C-lobe | Ezrin/radixin/moesin | Ezrin/radixin/moesin, alpha-helical domain | Ezrin/radixin/moesin, C-terminal | Ezrin/radixin/moesin-like | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | Moesin tail domain superfamily | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5TZG5
|
583 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kop:YPet-ezrb-UTR-nanos3,myl7:EGFP) |
| 1 | Olguin-Olguin et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-122H15 | ||
| Encodes | EST | cb567 | Thisse et al., 2001 | |
| Encodes | EST | fc05c03 | ||
| Encodes | EST | fj31d06 | ||
| Encodes | EST | IMAGE:7140274 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:161977 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030285 (1) | 2720 nt | ||
| Genomic | GenBank:BX248246 (2) | 176239 nt | ||
| Polypeptide | UniProtKB:Q5TZG5 (1) | 583 aa |
- Zhou, N., He, M., Zhou, G., Fan, Q., Qi, Y. (2024) Variant in EZR leads to defects in lens development. Ophthalmic genetics. 45(4):363-371
- Olguin-Olguin, A., Aalto, A., Maugis, B., Boquet-Pujadas, A., Hoffmann, D., Ermlich, L., Betz, T., Gov, N.S., Reichman-Fried, M., Raz, E. (2021) Chemokine-biased robust self-organizing polarization of migrating cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118(7):
- Prince, D.J., Jessen, J.R. (2019) Dorsal convergence of gastrula cells requires a Vangl2 and adhesion protein-dependent change in protrusive activity. Development (Cambridge, England). 146(22):
- Wen, Z.Y., Wang, J., Bian, C., Zhang, X., Li, J., Peng, Y., Zhan, Q., Shi, Q., Li, Y.Y. (2019) Molecular cloning of two kcnk3 genes from the Northern snakehead (Channa argus) for quantification of their transcriptions in response to fasting and refeeding. General and comparative endocrinology. 281:49-57
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sidhaye, J., Norden, C. (2017) Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis. eLIFE. 6
- Xu, W., Jin, M., Hu, R., Wang, H., Zhang, F., Yuan, S., Cao, Y. (2017) The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology : JASN. 28(1):118-129
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Diz-Muñoz, A., Romanczuk, P., Yu, W., Bergert, M., Ivanovitch, K., Salbreux, G., Heisenberg, C.P., Paluch, E.K. (2016) Steering cell migration by alternating blebs and actin-rich protrusions. BMC Biology. 14:74
- Celik, H., Hong, S.H., Colón-López, D.D., Han, J., Saygideger Kont, Y., Minas, T.Z., Swift, M., Paige, M., Glasgow, E., Toretsky, J.A., Bosch, J., Uren, A. (2015) Identification of novel ezrin inhibitors targeting metastatic osteosarcoma by screening open access malaria box. Molecular cancer therapeutics. 14(11):2497-507
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